Obagi Therapeutic Lotion 5% BPO is a powerful acne treatment containing 5% benzoyl peroxide (BPO) that penetrates deep into pores to kill Propionibacterium acnes — the bacteria responsible for breakouts. Designed as a core step in the Obagi CLENZIDerm M.D. System, it effectively treats pimples, blackheads, and whiteheads while reducing inflammation and redness.
With its lightweight, fast-absorbing formula, Obagi Therapeutic Lotion 5% BPO delivers targeted acne-fighting action without clogging pores or leaving residue. The micro-sized benzoyl peroxide particles enhance skin penetration for maximum efficacy and minimal irritation.
Ideal for oily and acne-prone skin, Obagi Therapeutic Lotion 5% BPO promotes a clearer, healthier complexion with continued use — helping restore smoothness, balance, and confidence.
For detailed application steps, see the How to Use tab.
Suggested Pairing
For best results, use Obagi CLENZIDerm Therapeutic Lotion as part of the full Obagi CLENZIDerm System:
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Obagi CLENZIDerm Foaming Cleanser – deeply cleanses and removes impurities.
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Obagi CLENZIDerm Pore Therapy – exfoliates and refines pores before treatment.
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MD Cosmeceuticals Oil Control Moisturizer – replenishes hydration while balancing oily skin.
Key Benefits:
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Targets and kills acne-causing bacteria
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Clears existing breakouts and prevents new ones
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Reduces inflammation and redness
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Helps refine texture and minimize pores
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Lightweight and fast-absorbing for daily use
Key Ingredients:
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Benzoyl Peroxide (5%) – Penetrates pores to kill acne-causing bacteria and reduce inflammation.
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Glycerin – Hydrates and soothes while preventing dryness.
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Dimethyl Isosorbide – Enhances penetration of active ingredients for improved results.
See the Full Ingredients tab for the complete INCI list.
Obagi CLENZIDerm Therapeutic Lotion remains one of the most effective benzoyl peroxide treatments for acne-prone skin. Its micro-sized particles allow deep penetration with minimal irritation, making it a powerful yet tolerable solution for persistent breakouts.
— Dr Matete Mathobela, Dermatologist and Founder of MD Cosmeceuticals
